An isthmocele appears as a fluid pouchlike defect in the anterior uterine wall at the site of a prior cesarean section and ranges in prevalence from 19% to 84%, a direct relation to the increase in cesarean sections performed worldwide. Many definitions have been suggested for the dehiscence resulting from cesarean sections, and we propose standardization with a single term for all cases-isthmocele. Patients are not always symptomatic, but symptoms typically include intermittent abnormal bleeding, pain, and infertility. Pregnancy complications that result from an isthmocele include ectopic pregnancy, low implantation, and uterine rupture. Magnetic resonance imaging and transvaginal ultrasound are the gold standard imaging techniques for diagnosis. Surgical treatment of an isthmocele is still a controversial issue but should be offered to symptomatic women or the asymptomatic patient who desires future pregnancy. When surgery is the treatment choice, laparoscopy guided by hysteroscopy, hysteroscopy alone, or vaginal repair are the best options depending on the isthmocele's characteristics and surgeon expertise.
Setubal, A., Alves, J., Osório, F., Guerra, A., Fernandes, R., Albornoz, J., & Sidiroupoulou, Z. (2018). Treatment for Uterine Isthmocele, A Pouchlike Defect at the Site of a Cesarean Section Scar. *Journal of minimally invasive gynecology*, *25*(1), 38-46. https://doi.org/10.1016/j.jmig.2017.09.022
Setubal A, Alves J, Osório F, Guerra A, Fernandes R, Albornoz J, et al. Treatment for Uterine Isthmocele, A Pouchlike Defect at the Site of a Cesarean Section Scar. J Minim Invasive Gynecol. 2018;25(1):38-46. doi:10.1016/j.jmig.2017.09.022
Setubal, Antonio, et al. "Treatment for Uterine Isthmocele, A Pouchlike Defect at the Site of a Cesarean Section Scar." *Journal of minimally invasive gynecology*, vol. 25, no. 1, 2018, pp. 38-46.
Harjee R et al., 2021Journal of Minimally Invasive Gynecology
Objective: To evaluate the efficacy of surgical management for isthmoceles in patients presenting with secondary infertility.
Data Sources: A systematic search was performed in MEDLINE, EMBASE, and C...
Dominguez JA et al., 2023Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
The purpose of this State-of-the-Art Review was to provide a strategic analysis, in terms of strengths, weaknesses, opportunities and threats (SWOT analysis), of the current evidence regarding the man...
Surgery > Uterine Surgery > Isthmocele RepairDiagnostics > Ultrasound > Transvaginal SonographyInfertility > Uterine Factors > Cesarean Scar Defect
Neutens S et al., 2026Journal of Minimally Invasive Gynecology
STUDY OBJECTIVE: To study whether bilateral nonpatency of fallopian tubes is correlated with a lower recurrence rate of endometriosis. DESIGN: Retrospective 2:1 matched case-control study. SETTING: ...
Bardet L et al., 2024Journal of Minimally Invasive Gynecology
STUDY Objective: To compare outcomes of vaginal surgery in women with moderate or severe symptomatic cesarean scar defect (with or without residual myometrium).
Design: Retrospective cohort study.
Set...