OBJECTIVE: To investigate the possibility of direct effects of metformin on ovarian steroidogenesis.
DESIGN: Cultured ovarian cells.
SETTING: Academic research environment.
PATIENT(S): Women und...
McCartney CR et al., 2003Seminars in Reproductive Medicine
Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism and chronic anovulation. Although the etiology of PCOS is unknown, perturbations of gonadotropin secretion are one of t...
OBJECTIVE: To examine the direct effect of metformin on thecal cell androgen production.
SETTING: Basic science research laboratory, University of Texas Southwestern, Dallas, Texas.
INTERVENTION(S...
OBJECTIVE: To evaluate the involvement of endogenous opiates in the pathophysiology of the hyperinsulinism in patients affected by polycystic ovary disease by administering naloxone and naltrexone. We...